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Cytochrome P450 CYP1B1 (190-198) [Homo sapiens]
Sequence: H2N-FLDPRPLTV-OH
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包装价格促销价数量
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1mg￥425.00340.00- +
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5mg￥1337.001070.00- +
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10mg￥2125.001700.00- +
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25mg￥3162.002530.00- +
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- 货号: ajcp4610
- CAS: N/A
- 别名: H2N-Phe-Leu-Asp-Pro-Arg-Pro-Leu-Thr-Val-OH
- 分子式: C50H80N12O13
- 分子量: 1057.24
- 纯度: ＞98%
- 溶解度: ≥105.7mg/mL in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
H2N-FLDPRPLTV-OH
Cytochrome P450 CYP1B1 is a dioxin-inducible form of the cytochrome P450 family of xenobiotic metabolizing enzymes1.
HLA-A2 restricted, CYP1B1 190–198 (CYP190) peptide speci?c T cell responses are induced in HLA-A2Kb transgenic mice by immunization with ZYC300, a PLG microparticle formulation that contains a plasmid DNA encoding the tumor associated antigen CYP1B12, 3.
Each successive co-application of EPT contributes to an escalating T cell response that can be observed 2 weeks after the last immunization, and that even a single EPT when given with the usually ineffective 30 μg dose of ZYC300 was able to induce a detectable CD8+ CYP190 speci?c T cell response4.
参考文献:
1. Murray,G.I., Taylor, M. C., et al 1997; Tumor-specific Expression of Cytochrome P450 CYP1B11. Cancer Research. 57:3026-3031.
2. Luby TM, Cole GA, Baker L, Kornher JS, Ramstedt U, Hedley ML. Repeated immunization with plasmid DNA formulated in poly(lactide-co-glycolide) microparticles is well tolerated and stimulates durable T cell responses to the tumor associated antigen cytochrome P450 1B1. Clinical Immunology 2004;112(1):45–53.
3. Maecker DH, Sherr RH, Vonderheide MS, von Bergwelt-Baildon MS, Hirano N, Anderson K, et al. The shared tumor-associated antigen cytochrome P450 1B1 is recognized by speci?c cytotoxic T cells. Blood 2003;102(9):3287–94.
4. Barbon, C. M., Baker, L et al 2010 In vivo electroporation enhances the potency of poly-lactide co-glycolide (PLG) plasmid DNA immunization. Vaccine; 28:7852-7864
