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Immunoglobulin M heavy chain (IGHM) fragment [Homo sapiens]
Immunoglobulin M heavy chain
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包装价格促销价数量
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1mg￥437.00350.00- +
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5mg￥1412.001130.00- +
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10mg￥2275.001820.00- +
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25mg￥2950.002360.00- +
![Immunoglobulin M heavy chain (IGHM) fragment [Homo sapiens]的Cell.Cell host & microbe.November 8, 2023引用](https://www.anjiechem.com/public/static/upload/images/goods/2023/12/19/1702965676740551.png)
![Immunoglobulin M heavy chain (IGHM) fragment [Homo sapiens]的Cell . MOLECULAR PLANT . 1 February 2023引用](https://www.anjiechem.com/public/static/upload/images/goods/2023/04/25/1682393851386824.png)
![Immunoglobulin M heavy chain (IGHM) fragment [Homo sapiens]的Cell . Immunity . August 10, 2021引用](https://www.anjiechem.com/public/static/upload/images/goods/2023/04/25/1682392700780709.png)
![Immunoglobulin M heavy chain (IGHM) fragment [Homo sapiens]的Nature Communications.1413 (2022)引用](https://www.anjiechem.com/public/static/upload/images/goods/2023/04/25/1682391081480957.png)
![Immunoglobulin M heavy chain (IGHM) fragment [Homo sapiens]的ACS . Nano Lett . April 10, 2023引用](https://www.anjiechem.com/public/static/upload/images/goods/2023/04/25/1682396014655366.png)
- 货号: ajcp4628
- CAS: N/A
- 别名: H2N-Gly-Val-Ala-Leu-His-Arg-Pro-Asp-Val-Tyr-Leu-Leu-Pro-Pro-Ala-Arg-OH
- 分子式: C82H132N24O20
- 分子量: 1774.07
- 纯度: ＞98%
- 溶解度: ≥177.4mg/mL in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
Immunoglobulin M heavy chain (IGHM) fragment [Homo sapiens] is a fragment (Gly-Val-Ala-Leu-His-Arg-Pro-Asp-Val-Tyr-Leu-Leu-Pro-Pro-Ala-Arg) on the the human immunoglobulin micro heavy chain.
Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions.
The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma.
参考文献:
1. Janeway CA, Jr et al. (2001). Immunobiology. (5th ed.). Garland Publishing. ISBN 0-8153-3642-X
2. Woof J, Burton D (2004). "Human antibody-Fc receptor interactions illuminated by crystal structures". Nat Rev Immunol 4 (2): 89–99.
