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prostate apoptosis response protein PAR-4 (2-7) [Homo sapiens]
Transcriptional repressor
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包装价格促销价数量
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1mg￥462.00370.00- +
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5mg￥1300.001040.00- +
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10mg￥2187.001750.00- +
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25mg￥3212.002570.00- +
![prostate apoptosis response protein PAR-4 (2-7) [Homo sapiens]的Cell.Cell host & microbe.November 8, 2023引用](https://www.anjiechem.com/public/static/upload/images/goods/2023/12/19/1702965676740551.png)
![prostate apoptosis response protein PAR-4 (2-7) [Homo sapiens]的Cell . MOLECULAR PLANT . 1 February 2023引用](https://www.anjiechem.com/public/static/upload/images/goods/2023/04/25/1682393851386824.png)
![prostate apoptosis response protein PAR-4 (2-7) [Homo sapiens]的Cell . Immunity . August 10, 2021引用](https://www.anjiechem.com/public/static/upload/images/goods/2023/04/25/1682392700780709.png)
![prostate apoptosis response protein PAR-4 (2-7) [Homo sapiens]的Nature Communications.1413 (2022)引用](https://www.anjiechem.com/public/static/upload/images/goods/2023/04/25/1682391081480957.png)
![prostate apoptosis response protein PAR-4 (2-7) [Homo sapiens]的ACS . Nano Lett . April 10, 2023引用](https://www.anjiechem.com/public/static/upload/images/goods/2023/04/25/1682396014655366.png)
- 货号: ajcp4646
- CAS: N/A
- 别名: H2N-Ala-Thr-Gly-Gly-Tyr-Arg-OH
- 分子式: C26H41N9O9
- 分子量: 623.66
- 纯度: ＞98%
- 溶解度: ≥62.3mg/mL in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
prostate apoptosis response protein PAR-4 (2-7) [Homo sapiens], (C26H41N9O9), a peptide with the sequence H2N-Ala-Thr-Gly-Gly-Tyr-Arg-OH, MW= 623.66. Prostate apoptosis response-4 (Par-4), is a human gene coding for a tumor-suppressor protein that induces apoptosis in cancer cells, but not in normal cells.The tumor suppressor PAR-4 represses and activates transcription. The protein encoded by this gene is a PAR-4-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of PAR-4. This protein is specifically upregulated during apoptosis of prostate cells1.The active domain of the Par-4 protein has been found to confer cancer resistance in transgenic mice without compromising normal viability or aging, and may have therapeutic significance2.
参考文献:
1. Johnstone, R W; See R H, Sells S F, Wang J, Muthukkumar S, Englert C, Haber D A, Licht J D, Sugrue S P, Roberts T, Rangnekar V M, Shi Y (Dec. 1996). "A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1". Mol. Cell. Biol. (UNITED STATES) 16 (12): 6945-56.
2. Zhao Y, Burikhanov R, Qiu S, Lele SM, JenningsCD, Bondada S, Spear B, Rangnekar VM (2007). "Cancer resistance in transgenic mice expressing the SAC module of Par-4". Cancer Res. 67 (19): 9276-85.
