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GTP binding protein 1 fragment [Multiple species]
Signal transducing molecules
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包装价格促销价数量
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1mg￥450.00360.00- +
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5mg￥1375.001100.00- +
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10mg￥2100.001680.00- +
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25mg￥3087.002470.00- +
![GTP binding protein 1 fragment [Multiple species]的Cell.Cell host & microbe.November 8, 2023引用](https://www.anjiechem.com/public/static/upload/images/goods/2023/12/19/1702965676740551.png)
![GTP binding protein 1 fragment [Multiple species]的Cell . MOLECULAR PLANT . 1 February 2023引用](https://www.anjiechem.com/public/static/upload/images/goods/2023/04/25/1682393851386824.png)
![GTP binding protein 1 fragment [Multiple species]的Cell . Immunity . August 10, 2021引用](https://www.anjiechem.com/public/static/upload/images/goods/2023/04/25/1682392700780709.png)
![GTP binding protein 1 fragment [Multiple species]的Nature Communications.1413 (2022)引用](https://www.anjiechem.com/public/static/upload/images/goods/2023/04/25/1682391081480957.png)
![GTP binding protein 1 fragment [Multiple species]的ACS . Nano Lett . April 10, 2023引用](https://www.anjiechem.com/public/static/upload/images/goods/2023/04/25/1682396014655366.png)
- 货号: ajcp4698
- CAS: N/A
- 别名: H2N-Lys-Val-Ile-Thr-Phe-Ile-Asp-Leu-OH
- 分子式: C46H77N9O12
- 分子量: 948.16
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
GTP binding protein 1 fragment [Multiple species], (C46H77N9O12), a peptide with the sequence H2N-Lys-Val-Ile-Thr-Phe-Ile-Asp-Leu-OH, MW= 948.16. G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins involved in transmitting chemical signals originating from outside a cell into the inside of the cell. G proteins function as molecular switches. Their activity is regulated by factors that control their ability to bind to and hydrolyze guanosine triphosphate (GTP) to guanosine diphosphate (GDP). When they bind GTP, they are 'on', and, when they bind GDP, they are 'off'. G proteins belong to the larger group of enzymes called GTPases(1). G proteins are important signal transducing molecules in cells. "Malfunction of GPCR [G Protein-Coupled Receptor] signaling pathways are involved in many diseases, such as diabetes, blindness, allergies, depression, cardiovascular defects, and certain forms of cancer. It is estimated that more than half of the modern drugs' cellular targets are GPCRs." (2)The human genome encodes roughly 950 G protein-coupled receptors, which detect photons (light), hormones, growth factors, drugs, and other endogenous ligands. Approximately 150 of the GPCRs found in the human genome have unknown functions.
Figure1? the structures of GTP binding protein
Figure 2 ?Mechanisms of GTP binding protein regulaltion
Ref:
1. Hurowitz EH, Melnyk JM, Chen YJ, Kouros-Mehr H, Simon MI, Shizuya H (2000). "Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes". DNA Res 7 (2): 111–20.
2. Wu G (2010). "Assays with GPCRs". Assay Development: Fundamentals and Practices.New York: Wiley.
