c-Myc tag Peptide
合成肽标签
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包装价格促销价数量
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5mg￥550.00440.00- +
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25mg￥2362.001890.00- +
- 货号: ajcp4712
- CAS: N/A
- 别名: H-Glu-Gln-Lys-Leu-Ile-Ser-Glu-Glu-Asp-Leu-OH
- 分子式: C51H86N12O21
- 分子量: 1203.3
- 纯度: ＞98%
- 溶解度: ≥60.165mg/mL in DMSO, ≥15.7 mg/mL in Water with ultrasonic
- 储存: Desiccate at -20°C
- 库存: 现货
Background
c-Myc Peptide is a useful displacement of c-Myc-tagged fusion proteins bound to anti-c-Myc antibodies in immunoassays. The successful inhibition of antibody binding by c-Myc peptide demonstrates binding is specific. c-Myc peptide participates in regulation of growth-related gene transcription.
The c-Myc Peptide is a synthetic peptide with an amino acid sequence that corresponds to the amino acids 410-419 of the C-terminal of human c-myc. Myc (c-Myc) is a regulator gene that codes for a transcription factor. c-Myc activation results in numerous biological effects. The first to be discovered was its capability to drive cell proliferation (upregulates cyclins, downregulates p21), but it also plays a very important role in regulating cell growth (upregulates ribosomal RNA and proteins), apoptosis (downregulates Bcl-2), differentiation and stem cell self-renewal. C-Myc is a very strong proto-oncogene and it is very often found to be upregulated in many types of cancers. c-Myc overexpression stimulates gene amplification, [1] presumably through DNA over-replication.
参考文献:
1. Denis N, Kitzis A, Kruh J, Dautry F, Corcos D (August 1991). "Stimulation of methotrexate resistance and dihydrofolate reductase gene amplification by c-myc". Oncogene 6 (8): 1453–7.
