Oroxin A
A flavonoid glycoside
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包装价格促销价数量
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1mg￥425.00340.00- +
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5mg￥1100.00880.00- +
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10mg￥1850.001480.00- +
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20mg￥3150.002520.00- +
- 货号: ajcn5888
- CAS: 57396-78-8
- 别名: 千层纸苷A
- 分子式: C21H20O10
- 分子量: 432.38
- 纯度: ＞98%
- 溶解度: DMSO : 125 mg/mL (289.10 mM; Need ultrasonic)
- 储存: Store at 2-8°C,protect from light
- 库存: 现货
Background
Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE), activates peroxisome proliferator-activated receptor γ (PPARγ) by docking into the PPARγ protein ligand-binding domain. Oroxin A exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity[1]. Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence[2].
Oroxin A (0.5- 100 μM; 24 hours) significantly increases the PPARγ transcription level and exhibits the strongest activation with 50 μM in HEK-293t cells[1].
参考文献:
[1]. Sun W, et al. Oroxin A from Oroxylum indicum prevents the progression from prediabetes to diabetes in streptozotocin and high-fat diet induced mice. Phytomedicine. 2018 Jan 1;38:24-34.
[2]. He J, et al. Oroxin A inhibits breast cancer cell growth by inducing robust endoplasmic reticulum stress and senescence. Anticancer Drugs. 2016 Mar;27(3):204-15.
