Anti-inflammatory agent 38
Anti-inflammatory agent 38(化合物23d)是一种有效的Nrf2/HO-1途径抑制剂，对NO的IC50值为0.38 μM。
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包装价格促销价数量
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1mg￥3950.003160.00- +
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5mg￥10050.008040.00- +
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- 货号: ajcf26010
- CAS: 3032633-42-1
- 别名:
- 分子式: C36H46N2O13S
- 分子量: 746.82
- 纯度: ＞98%
- 溶解度: DMSO : 100 mg/mL (133.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
- 储存: 4°C, protect from light
- 库存: 现货
Background
Anti-inflammatory agent 38 (compound 23d) is a potent Nrf2/HO-1 pathway inhibitor, with an IC50 value of 0.38 μM for NO. Anti-inflammatory agent 38 can significantly reduce the level of ROS in cells. Anti-inflammatory agent 38 can be used for researching anti-inflammatory.Anti-inflammatory agent 38 (compound 23d) (0.25, 0.5, 1 and 2 μM; 3 hours) can reduce ROS production in RAW264.7 cells stimulated with LPS (0.5 μg/mL LPS stimulates for 12 hours)[1].
Anti-inflammatory agent 38 (0.25, 0.5, 1 and 2 μM; 3 hours) significantly increases the expression of Nrf2 and HO-1 in LPS-stimulated RAW264.7 cells in a dose-dependent manner, and promoting LPS-induced Nrf2 nuclear translocation[1]
参考文献:
[1]. Wang W, et al. Synthesis of lathyrane diterpenoid nitrogen-containing heterocyclic derivatives and evaluation of their anti-inflammatory activities. Bioorg Med Chem.
