JAK-IN-24
JAK-IN-24是一种JAK抑制剂，在4μM或1mM ATP存在下的IC50分别为0.534和24 nM。
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1mg￥4037.003230.00- +
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- 货号: ajcf26466
- CAS: 2042629-43-4
- 别名:
- 分子式: C20H25N5O2
- 分子量: 367.44
- 纯度: ＞98%
- 溶解度: DMSO : 100 mg/mL (272.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
- 储存: 4°C, sealed storage, away from moisture and light
- 库存: 现货
Background
JAK-IN-24 is a JAK inhibitor, with IC50s of 0.534 and 24 nM at the presence of 4 μM or 1mM ATP, respectively. JAK-IN-24 also inhibits PBMC IL-15 induced STAT5 phosphorylation with an IC50 of 86.171 nM. JAK-IN-24 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.JAK-IN-24 (Example 129 ) inhibits JAK with IC50 values of 0.534 and 24 nM at the presence of 4 μM or 1mM ATP respectively[1].
JAK-IN-24 shows stability in human whole blood with t1/2 of 267.223 min[1].
JAK-IN-24 inhibits PBMC IL-15 induced STAT5 phosphorylation with an IC50 of 86.171 nM[1].
参考文献:
[1]. Atli Thorarensen, et al. Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, pyrrolo[2,3-b]pyridinyl acrylamides and epoxides thereof. Patent. WO2016178110.
