Calcitriol-d3
Calcitriol-d3 是 Calcitriol 的氘代物。
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包装价格促销价数量
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1mg￥63275.0050620.00- +
- 货号: ajcf29684
- CAS: 128723-16-0
- 别名: 骨化三醇-d3；钙三醇-d3；1,25-Dihydroxyvitamin D3-d3
- 分子式: C27H41D3O3
- 分子量: 419.65
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
Calcitriol-d3?is the deuterium labeled Calcitriol. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.
参考文献:
[1].?Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
[2].?Wang G, et al. Calcitriol Inhibits Cervical Cancer Cell Proliferation Through Downregulation of HCCR1 Expression. Oncol Res. 2014;22(5-6):301-9.?? [3].?Santos-Martínez N, et al. Calcitriol restores antiestrogen responsiveness in estrogen receptor negative breast cancer cells: a potential new therapeutic approach. BMC Cancer. 2014 Mar 2914:230.?
[4].?Dong J, et al. Calcitriol restores renovascular function in estrogen-deficient rats through downregulation of cyclooxygenase-2 and the thromboxane-prostanoid receptor. Kidney Int. 2013 Jul84(1):54-63.??[Content Brief] [5].?Chou CL, et al. Beneficial effects of calcitriol on hypertension, glucose intolerance, impairment of endothelium-dependent vascular relaxation, and visceral adiposity in fructose-fed hypertensive rats. PLoS One. 2015 Mar 1610(3):e0119843.
?Calcitriol-d3 是 Calcitriol 的氘代物。 Calcitriol 是活性最大的 vitamin D 代谢物，也是 vitamin D 受体 (VDR) 的激动剂。
