KRASG12D-IN-1(化合物22)是KRASG12D抑制剂。
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KRASG12D-IN-1 (compound 22) is a KRASG12D Inhibitor. KRASG12D-IN-1 has dose-dependent anti-tumor efficacy in the AsPC-1 xenograft mouse models with a tumor growth inhibition.
参考文献:
[1]. Xiao X, et al. Design, Synthesis, and Pharmacological Evaluation of Multisubstituted Pyrido[4,3-d]pyrimidine Analogues Bearing Deuterated Metlene Linkers as Potent KRASG12D Inhibitors. J Med Chem. 2023 Nov 3.