CC-647
CC-647 是一种分子胶 (molecular glue) 调节剂，靶向Cereblon(CRBN) E3 泛素连接酶。
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包装价格促销价数量
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5mg￥1475.001180.00- +
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10mg￥2375.001900.00- +
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25mg￥4587.003670.00- +
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- 货号: ajcf41026
- CAS: 1061605-35-3
- 别名:
- 分子式: C23H22N2O5
- 分子量: 406.43
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
CC-647 is amolecular gluemodulator targetingCereblon(CRBN) E3 ubiquitinligase. CC-647 promotes the interaction between CRBN and ZBTB16 as well as its oncogenic fusion protein RARα-ZBTB16 (with aDC50of 103 nM). CC-647 is promising for research of ZBTB16-RARα-associated acute promyelocytic leukemia (APL)[1].
参考文献:
[1].Matyskiela ME, et al. Cereblon Modulators Target ZBTB16 and Its Oncogenic Fusion Partners for Degradation via Distinct Structural Degrons. ACS Chem Biol. 2020 Dec 18;15(12):3149-3158.
