SI-W052
SI-W052 是一种具有口服活性、脑渗透性和选择性小分子抑制剂，靶向mTOR和TEX264。
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包装价格促销价数量
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5mg￥2400.001920.00- +
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10mg￥3737.002990.00- +
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- 货号: ajcf41036
- CAS: 2572552-60-2
- 别名:
- 分子式: C20H19ClN2O5S
- 分子量: 434.89
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
SI-W052 is an orally active, brain-penetrant and selective small-molecule inhibitor targetingmTORandTEX264. SI-W052 activatesautophagyby inhibitingmTORphosphorylation and enhances TEX264 expression to promote ER turnover, suppressing LPS-induced release of inflammatory factors (TNF-α,IL-6). SI-W052 is promising for research of Alzheimer’s disease (AD)-associated neuroinflammation[1].
参考文献:
[1].Wang Z, et al. Anti-Inflammatory Anthranilate Analogue Enhances Autophagy through mTOR and Promotes ER-Turnover through TEX264 during Alzheimer-Associated Neuroinflammation. ACS Chem Neurosci. 2022 Feb 2;13(3):406-422.
