Succinyl CoA（琥珀酰辅酶 A）
Succinyl CoA 是一种柠檬酸循环的中间体。Succinyl CoA 可转化为琥珀酸，也可通过 δ-amino levulinic acid (ALA) 合成酶的催化，与甘氨酸结合形成 δ-ALA 从而合成卟啉 (血红素)。Succinyl CoA 可用于营养性维生素 B12 缺乏症 (致使 Succinyl CoA 合成缺乏) 所引起的代谢、神经学和血液学异常 (如卟啉症) 的研究。
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包装价格促销价数量
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1mg￥1500.00700.00- +
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5mg￥4375.002500.00- +
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10mg￥6250.004000.00- +
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100mg￥18000.000.00- +
- 货号: ajci76488
- CAS: 604-98-8
- 别名: 琥珀酰辅酶 A;丁二酰辅酶 A;Succinyl-CoA;Succinyl-coenzyme A；S-(Hydrogen succinyl)coenzyme A
- 分子式: C25H40N7O19P3S
- 分子量: 867.61
- 纯度: ＞95%
- 溶解度: Soluble in DMSO;Soluble in water
- 储存: Store at -20°C
- 库存: 现货
Background
Succinyl CoA is an intermediate of the citric acid cycle. Succinyl CoA can be converted to succinic acid and can also combines with glycine to form δ-amino levulinic acid (ALA) to synthesize porphyrins (heme). Succinyl CoA can be used in the study of metabolic, neurological and haematological abnormalities (such as porphyrias) caused by nutritional vitamin B12 deficiency (resulting in a deficiency in Succinyl CoA synthesis)[1][2].
Application：
琥珀酰辅酶A钠盐已用于：
体外赖氨酸的非酶促琥珀酰化，
用作重组大肠杆菌中的己二酸生物合成底物 [3]
蛋白质琥珀酰化的异柠檬酸脱氢酶（ICDH）处理
用作底物，研究酶，比如乙酸盐：琥珀酸辅酶A转移酶和5-氨基乙酰丙酸合成酶（ALA合成酶）的特异性和动力学。
Biochem/physiol Actions
琥珀酰辅酶A在柠檬酸循环中是中间体。 它通过α-酮戊二酸脱氢酶催化α-酮戊二酸脱羧。琥珀酰辅酶A也可在单链脂肪酸β-氧化过程中由丙酰辅酶A形成。[4]琥珀酰辅酶A在血红素合成中作为前体。它还可以用于酮体氧化。
参考文献：
[1]. Bicakci Z. Growth retardation, general hypotonia, and loss of acquired neuromotor skills in the infants of mothers with cobalamin deficiency and the possible role of succinyl-CoA and glycine in the pathogenesis. Medicine (Baltimore). 2015 Mar;94(9):e584.
[2]. Bonkovsky HL, et al. Porphyrin and heme metabolism and the porphyrias. Compr Physiol. 2013 Jan;3(1):365-401.
[3].Jia-Le Yu, Xiao-Xia Xia, Jian-Jiang Zhong,et al.Direct biosynthesis of adipic acid from a synthetic pathway in recombinant Escherichia coli.Biotechnology and bioengineering (2014-06-05)
[4].Suzana Savvi, Digby F Warner, Bavesh D Kana, John D McKinney,,et al.Functional characterization of a vitamin B12-dependent methylmalonyl pathway in Mycobacterium tuberculosis: implications for propionate metabolism during growth on fatty acids.Journal of bacteriology (2008-04-01)
