TH-1(酪氨酸羟化酶荧光探针)|安捷凯

TH-1(酪氨酸羟化酶荧光探针)

TH-1是一种酪氨酸羟化酶免洗比率荧光探针。帕金森病（Parkinson’s Disease）是第二大常见的神经退行性疾病。酪氨酸羟化酶（TH）是产生多巴胺的关键酶，其水平可作为评估PD严重程度和进展的指标。TH-1在SH-SY5Y神经细胞中表现出理想的光物理特性和TH活性的特异性双通道生物成像。此外，该探针还可以对斑马鱼大脑和活体小鼠纹状体切片中的 TH 活性进行体内成像。总体而言，比率荧光探针TH-1可以作为复杂生物系统中 PD 实时监测的潜在工具。λex = 488nm, λem = 675-740nm

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Background

Parkinson’s disease (PD) represents the second most widespread neurodegenerative disease, and early monitoring and diagnosis are urgent at present. Tyrosine hydroxylase (TH) is a key enzyme for producing dopamine, the levels of which can serve as an indicator for assessing the severity and progression of PD. This renders the specific detection and visualization of TH a strategically vital way to meet the above demands. However, a fluorescent probe for TH monitoring is still missing. Herein, three rationally designed wash-free ratiometric fluorescent probes were proposed. Among them, TH-1 exhibited ideal photophysical properties and specific dual-channel bioimaging of TH activity in SH-SY5Y nerve cells. Moreover, the probe allowed for in vivo imaging of TH activity in zebrafish brain and living striatal slices of mice. Overall, the ratiometric fluorescent probe TH-1 could serve as a potential tool for real-time monitoring of PD in complex biosystems.¹

参考文献:

1.Jia-Yi Yao, Lu Li, Ji-Xuan Xu, et al. Real-Time Monitoring of Tyrosine Hydroxylase Activity with a Ratiometric Fluorescent Probe.ACS Publications. Anal. Chem. 2024, 96, 7082−7090

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TH-1(酪氨酸羟化酶荧光探针)

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Background

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