ProSeMet
ProSeMet 可通过化学酶法在细胞内和体内转化为S-腺苷甲硫氨酸（SAM）类似物ProSeAM，将带有生物正交属性的炔基标记到蛋白质上。该标记既可以直接通过液相色谱-串联质谱（LC-MS/MS）进行检测，也可经功能化修饰后完成后续的选择性富集，再通过LC-MS/MS完成鉴定。
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包装价格促销价数量
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5mg￥5000.004000.00- +
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10mg￥6250.005000.00- +
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25mg￥10625.008500.00- +
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50mg￥18750.0015000.00- +
- 货号: ajci76492
- CAS: N/A
- 别名: (2S)-2-Amino-4-(2-propyn-1-ylseleno)butanoic acid;(2S)-2-氨基-4-(2-丙炔-1-基硒基)丁酸
- 分子式: C7H11NO2Se
- 分子量: 220.13
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
ProSeMet, that is chemo enzymatically converted to the SAM analogue ProSeAM in cells and in vivo to tag proteins with a biorthogonal alkyne that can be directly detected via liquid chromatography and tandem mass spectrometry (LC-MS/MS), or functionalized for subsequent selective enrichment and LC-MS/MS identification.1
Systemic ProSeMet delivery in mice propargylates proteins across organ systems with blood−brain barrier penetrance and identifies site-specific propargylation in vivo with LC-MS/MS. Leveraging these pipelines to define the cellular methylproteome may have broad applications for understanding the methylproteome in the context of disease.1
参考文献：
1.Jonathan Farhi, Benjamin Emenike,Richard S, et al.Dynamic In Vivo Mapping of the Methylproteome Using a Chemoenzymatic Approach.J. Am. Chem. Soc. 2025, 147, 7214−7230
