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Crebanine
An aporphine alkaloid with diverse biological activities
BX-912
A potent inhibitor of PDK1
FRATide
GSK-3 inhibitor
eCF309
A selective mTOR inhibitor
OTSSP167
A potent inhibitor of MELK
ON 146040
ON 146040 是一种有效的 PI3Kα 和 PI3Kδ 抑制剂,IC50 分别约为 14 和 20 nM。ON 146040 也抑制 Abl1 (IC50<150 nM)。
PI3Kγ inhibitor 1
PI3Kγ inhibitor 1 是一种 PI3Kδ 和 PI3Kγ 抑制剂,详细信息请参考专利文献 WO2014004470A1 中 Table 4 中的化合物 168。PI3Kγ inhibitor 1 抑制 PI3Kδ 和 PI3Kγ,IC50<100 nM。
GSK2110183
Afuresertib (GSK2110183) is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.
Seco Rapamycin
A degradation product of rapamycin
PS 48
PDK1激活剂
Afzelin
A polyphenolic glycoside flavone with diverse biological activities
CHIR 99021 trihydrochloride
A selective GSK3 inhibitor
Buparlisib
Buparlisib (BKM120; NVP-BKM120) 是一种 pan-class I PI3K 抑制剂,作用于 p110α/p110β/p110δ/p110γ,IC50 分别为 52 nM/166 nM/116 nM/262 nM。
PKI-179 (hydrochloride)
A dual PI3K and mTOR inhibitor
Auraptene
A coumarin derivative with anti-inflammatory and chemopreventative activity