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AS-604850
A selective inhibitor of PI3Kγ
PQR620
PQR620 is a novel, selective, orally bioavailable and brain penetrant dual TORC1/2 inhibitor. PQR620 has anti-tumor activity across 56 lymphoma models with a median IC50 of 250 nM after 72 h of exposure.
NSC781406
A dual inhibitor of PI3K and mTOR
PI3Kα/mTOR-IN-1
PI3Kα/mTOR-IN-1 是一种有效的 PI3Kα/mTOR 双重抑制剂,在细胞实验中对 PI3Kα 的 IC50 值为 7 nM,在体外酶实验中对 mTOR 和 PI3Kα 的 Ki 值分别为 10.6 nM 和 12.5 nM。
Akt1 and Akt2-IN-1
Akt1andAkt2-IN-1是一种有效的变构抑制剂,抑制Akt1(IC50=3.5nM)和Akt2(IC50=42nM)。
AZD8835
An inhibitor of PI3Kα and PI3Kδ
Acalisib (GS-9820)
An inhibitor of p110δ
MELK-8a hydrochloride
A MELK inhibitor
Crosstide
A peptide substrate for Akt
Ipatasertib dihydrochloride (GDC-0068 (dihydrochloride))
A pan-Akt inhibitor
Tideglusib
A neuroactive thiadiazolidinone
GSK-3 inhibitor 1
GSK-3 inhibitor 1 是 GSK-3 抑制剂。
GDC-mTOR inhibitor
GDC-mTOR inhibitor 是一种具有显着选择性的 mTOR 抑制剂,Ki 为 1.5 nM。 GDC-mTOR inhibitor 在细胞和体内药代动力学 (PK)/药效学 (PD) 实验中抑制 mTORC1 和 mTORC2。
Loureirin A
Loureirin A is a flavonoid extracted from the red resin of the herbs of Dracaena cochinchinensis, which is known as Dragon's Blood. Loureirin A inhibits platelet activation by an impairment of PI3K/Akt signaling. Loureirin A inhibits Akt phosphorylation.
AKT inhibitor VIII
A potent inhibitor of Akt1 and Akt2