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SP 141
An inhibitor of MDM2
Nutlin-3a chiral
An inhibitor of the p53-Mdm2 interaction
YH239-EE
A prodrug form of YH 239
MI-773 (SAR405838)
An inhibitor of MDM2-p53 protein-protein interactions
RG7388
An inhibitor of the MDM2-p53 interaction
JNJ-26854165 (Serdemetan)
An antagonist of MDM2 action
Nutlin-3b
The less active enantiomer of (–)-nutlin-3
NVP-CGM097
RITA (NSC 652287)
An inhibitor of the p53-HDM-2 interaction
RG7112
NSC 66811
A potent inhibitor of Mdm2-p53 interaction
(±)-Nutlin-3
A racemic mixture of (?)-nutlin-3 and (+)-nutlin-3
AMG232
An inhibitor of the MDM2 and p53 interaction
Nutlin-3
MI-773
MI-773 是一种有效的 MDM2-p53 蛋白-蛋白相互作用 (PPI) 抑制剂,对 MDM2 具有高结合亲和力 (Kd=8.2 nM)。 MI-773 具有抗肿瘤活性。