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BRD0705
BRD0705 is a potent, paralog selective and orally active inhibitor of GSK3α (Glycogen synthase kinase 3α) with IC50 of 66 nM and Kd of 4.8 μM. BRD0705 also inhibits GSK3β with IC50 of 515 nM. BRD0705 can be used for acute myeloid leukemia (AML).
BRD5648
BRD5648 ((R)-BRD0705) 是一种无活性的 BRD0705 的 R 型异构体,BRD0705 是一种有效的,具有旁系选择性和口服活性的 GSK3α 抑制剂,IC50 为 66 nM,Kd 为 4.8 μM。BRD0705 与 GSK3β (IC50 为 515 nM) 相比,对 GSK3α 的选择性更高 (8 倍)。BRD0705 可用于急性髓细胞性白血病。
Indirubin
A natural inhibitor of GSK3 and CDK isoforms
SB 216763
SB 216763 stands out as a powerful, selective, and ATP-competitive inhibitor of GSK-3, effectively targeting both GSK-3α and GSK-3β with an impressive?IC50?of 34.3 nM[1-3].
CHIR 99021 trihydrochloride
A selective GSK3 inhibitor
CHIR-99021 (CT99021)
一种选择性的GSK3抑制剂
IM-12
A GSK3β inhibitor
BIO-acetoxime
A potent, selective inhibitor of GSK3α/β
Tideglusib
A neuroactive thiadiazolidinone
CHIR-98014
A reversible, cell-permeable inhibitor of GSK3
TDZD-8
A selective inhibitor of GSK3β
TWS119
SB 415286
A selective inhibitor of GSK-3
AZD2858
GSK-3 Inhibitor IX (BIO)
A potent, selective, and reversible GSK3 inhibitor