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BRD0705
BRD0705 is a potent, paralog selective and orally active inhibitor of GSK3α (Glycogen synthase kinase 3α) with IC50 of 66 nM and Kd of 4.8 μM. BRD0705 also inhibits GSK3β with IC50 of 515 nM. BRD0705 can be used for acute myeloid leukemia (AML).
BRD5648
BRD5648 ((R)-BRD0705) 是一种无活性的 BRD0705 的 R 型异构体,BRD0705 是一种有效的,具有旁系选择性和口服活性的 GSK3α 抑制剂,IC50 为 66 nM,Kd 为 4.8 μM。BRD0705 与 GSK3β (IC50 为 515 nM) 相比,对 GSK3α 的选择性更高 (8 倍)。BRD0705 可用于急性髓细胞性白血病。
GSK-3484862
GSK-3484862 是 DNA 甲基转移酶 Dnmt1 的非共价抑制剂,通过诱导 DNA 低甲基化起抗癌作用。
TDZD-8
A selective inhibitor of GSK3β
TC-G 24
TC-G 24 (Compound 24) 是一种有效的、选择性的糖原合酶激酶-3β (GSK-3β) 抑制剂,IC50 为 17.1 nM。
Indirubin
A natural inhibitor of GSK3 and CDK isoforms
A 1070722
A GSK3β inhibitor
3F8
3F8 是一种有效且选择性的 GSK-3β 抑制剂,可用作 GSK3 相关疾病的新试剂和潜在治疗候选物。
CHIR-98014
A reversible, cell-permeable inhibitor of GSK3
BIO-acetoxime
A potent, selective inhibitor of GSK3α/β
SB 216763
SB 216763 stands out as a powerful, selective, and ATP-competitive inhibitor of GSK-3, effectively targeting both GSK-3α and GSK-3β with an impressive?IC50?of 34.3 nM[1-3].
1-Azakenpaullone
A potent inhibitor of GSK3β
L803-mts
Selective peptide inhibitor of glycogen synthase kinase-3 (GSK-3)
SB 415286
A selective inhibitor of GSK-3
GSK-3 Inhibitor IX (BIO)
A potent, selective, and reversible GSK3 inhibitor