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Urapidil
An α1-AR antagonist and 5-HT1A receptor partial agonist
Tandospirone citrate
Tandospirone (SM-3997), a potent and selective 5-HT1A receptor partial agonist, with a Ki of 27 nM, has anxiolytic and antidepressant activities.
SB-277011
SB-277011是可渗透入脑的多巴胺D3受体拮抗剂,对D3,D2,5-HT1D和5-HT1B的pKi分别为8.0,6.0,5.0和<5.2。
SB-269970
A 5-HT7A and adrenergic α2 receptor antagonist
SB 271046 Hydrochloride
An orally-available 5-HT6 antagonist
SB 258719
SB 258719 是一个有选择性的 5-HT7 受体拮抗剂,其 pKi 值为 7.5。
RU 24969
A 5-HT1A and 5-HT1B receptor agonist
Risperidone mesylate
An atypical antipsychotic
Risperidone hydrochloride
Pipamperone
Pipamperone (Floropipamide; McN-JR 3345; R 3345) 是 5-HT2A 受体 (pKi=8.2) 和 D4 受体 (pKi=8.0) 的高亲和力拮抗剂。Pipamperone (Floropipamide; McN-JR 3345; R 3345) 是 D2 受体 (pKi=6.7) 的低亲和力拮抗剂。
Pimavanserin tartrate
A 5-HT2A inverse agonist
Piboserod hydrochloride
Piboserod (SB 207266)盐酸盐是5-羟色胺受体5-HT4选择性抑制剂。
Palonosetron
Palonosetron (RS25259, RS 25259 197) is a 5-HT3 antagonist with Ki value of 0.17 nM. It is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).
Masupirdine free base
Masupirdine free base (SUVN-502 free base) 是一种有效的,选择性的,具有口服生物可利用且可穿透脑屏障的5-HT6 受体拮抗剂 (对人 5-HT6 受体的 Ki 为 2.04 nM)。Masupirdine free base (SUVN-502 free base) 对 5-HT2A 受体和其他 100个 靶点显示高选择性,有治疗阿尔茨海默病的潜力。
LY334370
A 5-HT1F receptor agonist