Ciliobrevin D

Ciliobrevin D (compound 5) is a cell-permeable, reversible and specific antagonist of AAA+ (ATPases associated with diverse cellular activities) ATPase motor cytoplasmic dynein. Ciliobrevin D perturbs primary cilia formation and blocks Hedgehog (Hh) signa

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库存: 现货

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5mg

￥1737.00

1390.00

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10mg

￥2725.00

2180.00

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50mg

￥7775.00

6220.00

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货号: ajcx16480
CAS: 1370554-01-0
别名:
分子式: C17H8Cl3N3O2
分子量: 392.62
纯度: >98%
溶解度: DMSO: 5 mg/mL (12.73 mM; ultrasonic and warming and heat to 80°C)
储存: Store at -20°C
库存: 现货

Background

Ciliobrevin D inactivate dynein in Sertoli cells. The inactivation of dynein by ciliobrevin D also perturbs gross disruption of F-actin across the Sertoli cells in vitro.[2] Ciliobrevin D perturbs protein trafficking within the primary cilium, leading to their malformation and Hedgehog signaling blockade. Ciliobrevin D also prevents spindle pole focusing, kinetochore-microtubule attachment, melanosome aggregation, and peroxisome motility in cultured cells.[1]

Ciliobrevin D inactivate dynein in the testis. The inactivation of dynein by ciliobrevin D also perturbs gross disruption of F-actin across the seminiferous epithelium in vivo, illustrating there are cross talks between the two cytoskeletons in the testis.[2]

[1] Ari J Firestone, et al. Nature. 2012 Mar 18;484(7392):125-9. [2] Qing Wen, et al. Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E924-E948.