Paclitaxel octadecanedioate

A prodrug form of paclitaxel

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库存: 现货

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价格

促销价

数量
500ug

￥600.00

480.00

- +
1mg

￥1012.00

810.00

- +
5mg

￥4762.00

3810.00

- +
10mg

￥7737.00

6190.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajcx19976
CAS: 2089211-45-8
别名: 1,18-Octadecanedioic Acid-Paclitaxel, ODDA-PTX, PTX-FA18
分子式: C65H83NO17
分子量: 1150.4
纯度: >98%
溶解度: DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml,DMSO: 25 mg/ml,Ethanol: 20 mg/ml
储存: Store at -20°C
库存: 现货

Background

Paclitaxel octadecanedioate is a prodrug form of paclitaxel that is comprised of paclitaxel conjugated to 1,18-octadecanedioic acid.1 Unlike paclitaxel, it does not promote tubulin polymerization in vitro when used at a concentration of 10 μM. A 5:1 mixture of paclitaxel octadecanedioate:human serum albumin (HSA) is cytotoxic to HT-1080, PANC-1, and HT-29 cells (IC50s = 12, 2.48, and 8.62 nM, respectively). This mixture reduces tumor growth and increases survival in an HT-1080 mouse xenograft model in a dose-dependent manner.

|1. Callmann, C.E., Leguyader, C.L.M., Burton, S.T., et al. Antitumor activity of 1,18-octadecanedioic acid-paclitaxel complexed with human serum albumin. J. Am. Chem. Soc. 141(30), 11765-11769 (2019).