Colchicine-d6

An internal standard for the quantification of colchicine

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1mg

￥6462.00

5170.00

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货号: ajcx22126
CAS: 1217651-73-4
别名: 秋水仙素 d6
分子式: C22H19D6NO6
分子量: 405.5
纯度: >98%
溶解度: Chloroform: Slightly Soluble,Methanol: Slightly Soluble
储存: Store at -20°C
库存: 现货

Background

Colchicine-d₆ is intended for use as an internal standard for the quantification of colchicine by GC- or LC-MS. Colchicine is an inhibitor of microtubule polymerization (IC₅₀ = 3.2 μM) that binds to tubulin, which disrupts spindle formation during mitosis.¹ It inhibits growth of MCF-7 human breast carcinoma cells with an IC₅₀ value of 13 nM.¹ Colchicine has anti-inflammatory activity, inhibiting neutrophil motility and activity when used at a dose of 5 μmol/kg in a mouse model of gout and preventing the deposition of uric acid.^2,3

1.Martino, G.D., Regina, G.L., Coluccia, A., et al.Arylthioindoles, potent inhibitors of tubulin polymerizationJ. Med. Chem.47(25)6120-6123(2004) 2.McCarty, D.J.Urate crystals, inflammation, and colchicineArthritis Rheum.58(2)S20-S24(2008) 3.Chia, E.W., Grainger, R., and Harper, J.L.Colchicine suppresses neutrophil superoxide production in a murine model of gouty arthritis: A rationale for use of low-dose colchicineBr. J. Pharmacol.153(6)1288-1295(2008)