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  • Colchicoside
Colchicoside的可视化放大

Colchicoside

A glycoside form of 3-demethylcolchicine

原价
¥512-3375
价格
410-2700
Colchicoside的二维码

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  • 库存: 现货
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  • 货号: ajcx22128
  • CAS: 477-29-2
  • 别名: 秋水仙碱苷
  • 分子式: C27H33NO11
  • 分子量: 547.6
  • 纯度: >98%
  • 溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Colchicoside is a glycoside form of 3-demethylcolchicine that has been found in G. superba.1 Unlike cholchicine and 3-demethylcolchicine, colchicoside does not displace [3H]-colchicine from rat brain tubulin in vitro when used at a concentration of 25 μM.2 Colchicoside (1 and 10 μM) increases levels of the cytochrome P450 (CYP) isoforms CYP2C9 and CYP2E1 in primary human hepatocytes.3



1.Capistrano, I.R., Vangestel, C., Vanpachtenbeke, H., et al.Coadministration of a Gloriosa superba extract improves the in vivo antitumoural activity of gemcitabine in a murine pancreatic tumour modePhytomedicine23(12)1434-1440(2016) 2.Sugio, K., Maruyama, M., Tsurufuji, S., et al.Separation of tubulin-binding and anti-inflammatory activity in colchicine analogs and congenersLife Sci.40(1)35-39(1987) 3.Dvorák, Z., Ulrichová, J., ModrianskY, M., et al.Effect of colchicine and its derivatives on the expression of selected isoforms of cytochrome P450 in primary cultures of human hepatocytesActa Univ. Palacki. Olomuc. Fac. Med.14347-50(2000)

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