Withanone

A phytochemical with diverse biological activities

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库存: 现货

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500ug

￥1337.00

1070.00

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1mg

￥2425.00

1940.00

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5mg

￥10675.00

8540.00

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货号: ajcx24928
CAS: 27570-38-3
别名: NSC 179884
分子式: C28H38
分子量: 470.6
纯度: >98%
溶解度: Chloroform: soluble,Ethyl Acetate: slightly soluble,Methanol: slightly soluble
储存: -20°C
库存: 现货

Background

Withanone is a phytochemical that has been found in W. somnifera and has diverse biological activities.^1,2,3 It inhibits the protein-protein interaction between human angiotensin-converting enzyme 2 (ACE2) and the SARS-CoV-2 spike protein receptor-binding domain (IC₅₀ = 0.33 ng/ml).¹ Withanone (10 µg/ml) protects against DNA damage, oxidative stress, and premature senescence induced by the industrial contaminant methoxyacetic acid in TIG-1 human fibroblasts.² In vivo, withanone (5-20 mg/kg) decreases brain levels of amyloid-β 1-42 (Aβ42), malondialdehyde (MDA), TNF-α, IL-1β, and IL-6, increases brain levels of acetylcholine, and improves cognitive function in a rat model of streptozotocin-induced sporadic Alzheimer’s disease.³

1.Balkrishna, A., Pokhrel, S., Singh, H., et al.Withanone from Withania somnifera attenuates SARS-CoV-2 RBD and host ACE2 interactions to rescue spike protein induced pathologies in humanized zebrafish modeDrug Des. Devel. Ther.151111-1133(2021) 2.Priyandoko, D., Ishii, T., Kaul, S.C., et al.Ashwagandha leaf derived withanone protects normal human cells against the toxicity of methoxyacetic acid, a major industrial metabolitePLoS One6(5)e19552(2011) 3.Pandey, A., Bani, S., Dutt, P., et al.Multifunctional neuroprotective effect of withanone, a compound from Withania somnifera roots in alleviating cognitive dysfunctionCytokine102211-221(2018)