R-8507

An antagonist of TNF-α receptor signaling

原价

￥600-11912

价格

￥ 480-9530

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库存: 现货

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产品引用

货号: ajci73846
CAS: 338773-13-0
别名:
分子式: C16H8ClF3N4
分子量: 348.7
纯度: >98%
溶解度: DMF: 16 mg/ml,DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml,DMSO: 2 mg/ml
储存: Store at -20°C
库存: 现货

Background

R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI). It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 µM, respectively, in an ELISA using A549 lung epithelial cells.{|Gururaja2007|} It also disrupts the interaction of the TNF-αRI with receptor interacting protein 1 (RIP1) and TNF-αR-associated death domain protein (TRADD), preventing internalization of the receptor complex.

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生命科学

有机化学

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材料科学

R-8507

R-8507详情

Background