QN523

An anticancer agent

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库存: 现货

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包装

价格

促销价

数量
1mg

￥300.00

240.00

- +
5mg

￥1387.00

1110.00

- +
10mg

￥2450.00

1960.00

- +
25mg

￥4875.00

3900.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

QN523 is an anticancer agent.¹ It is cytotoxic to MiaPaCa-2, PANC-1, and BxPC-3 pancreatic cancer cells (IC₅₀s = 0.11, 0.5, and 3.3 µM, respectively). QN523 (0.5 µM) induces cell cycle arrest at the S phase in MiaPaCa-2 cells. It increases levels of the endoplasmic reticulum (ER) stress markers glucose-regulated protein 78 kDa (GRP78), DNA damage inducible transcript 3 (DDIT3), activating transcription factor 3 (ATF3), and growth differentiation factor 15 (GDF15), as well as the autophagy markers WD repeat domain phosphoinositide-interacting protein 1 (WIPI1), GABA_A receptor-associated protein-like 1 (GABARAPL1), and LC3-II in MiaPaCa-2 cells in a concentration-dependent manner. QN523 reduces tumor volume in a MiaPaCa-2 mouse xenograft model.

1.Kuang, Y., Ye, N., Kyani, A., et al.Induction of genes implicated in stress response and autophagy by a novel quinolin-8-yl-nicotinamide QN523 in pancreatic cancerJ. Med. Chem.65(8)6133-6156(2022)