Lenalidomide-OH

Lenalidomide-OH 是一种用于 E3 泛素连接酶的 cereblon (CRBN) 配体 Lenalidomide 的类似物，用于 CRBN 蛋白的募集。Lenalidomide-OH 可通过 linker 连接到蛋白质配体上形成 PROTAC，如 PROTAC BTK 降解剂 SJF620 。

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库存: 现货

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100mg

￥1462.00

1170.00

- +
500mg

￥4362.00

3490.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620 [1].

Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].

[1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.