Previtamin D3

An intermediate in the synthesis of vitamin D3

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1mg

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货号: ajcx29610
CAS: 1173-13-3
别名: 3Β,6Z-9,10-断胆甾基-5(10),6,8-三烯甘油酯-3
分子式: C27H44O
分子量: 384.64
纯度: >98%
溶解度: DMSO: 10 mM
储存: -20°C, protect from light, stored under nitrogen
库存: 现货

Background

Previtamin D₃ is an intermediate in the synthesis of the calcitriol precursor vitamin D₃ .^1,2 It is formed from 7-dehydro cholesterol in the epidermis via photolytic conversion by UVB radiation and is isomerized to vitamin D₃. The rate of previtamin D₃ synthesis is dependent on the solar zenith angle, which is affected by the latitude, season, and time of day. It is also dependent on the level of skin pigmentation and age, among other factors, with a negative correlation to higher pigmentation and age.^3,2,4

1.Rosen, C.J.Vitamin D insufficiencyN. Engl. J. Med.364(3)248-254(2011) 2.Chen, T.C., Chimeh, F., Lu, Z., et al.Factors that influence the cutaneous synthesis and dietary sources of vitamin DArch. Biochem. Biophys.460(2)213-217(2007) 3.Holick, M.F., Chen, T.C., Lu, Z., et al.Vitamin D and skin physiology: A D-lightful storyJ. Bone Miner. Res.22 Suppl 2.V28-33(2007) 4.Webb, A.R.Who, what, where and when-influences on cutaneous vitamin D synthesisProg. Biophys. Mol. Biol.92(1)17-25(2006)