现货大促销,价格低至8折起,量大更优惠,详细咨询客服
全部分类
全部分类
  • Lenalidomide-I
Lenalidomide-I的可视化放大

Lenalidomide-I

Lenalidomide-I 是一种用于 E3 泛素连接酶的 cereblon (CRBN) 配体 Lenalidomide 的类似物,用于 CRBN 蛋白的募集。Lenalidomide-I 可通过 linker 连接到蛋白质配体上形成 PROTAC,如 PROTAC BET 降解剂 QCA570 。

原价
¥3775-6262
价格
3020-5010
Lenalidomide-I的二维码

所有产品仅用于科学研究,我们不为任何个人用途提供产品和服务

询价有惊喜,量大更优惠 点击这里给我发消息

  • 库存: 现货
可选包装 >>>
首页
  • 货号: ajcx33146
  • CAS: 2207541-30-6
  • 别名: 3-(4-碘-1-氧代异吲哚啉-2-基)哌啶-2,6-二酮
  • 分子式: C13H11IN2O3
  • 分子量: 370.14
  • 纯度: >98%
  • 溶解度: DMSO : 25 mg/mL (67.54 mM; Need ultrasonic)
  • 储存: Store at -20°C
  • 库存: 现货

Background

Lenalidomide-I (Compound 72), an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570 [1].


Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].


[1]. Qin C, et, al. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J Med Chem. 2018 Aug 9;61(15):6685-6704.

动态评分

0.0

没有评分数据
没有评价数据
一键回到顶部
展开 收缩
安捷凯在线客服