安捷凯生物医药
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  • (S,R,S)-AHPC
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(S,R,S)-AHPC

(S,R,S)-AHPC (MDK7526, VH032-NH2, VHL ligand 1) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC is potential useful for the targeted degradation of the androgen receptor. (S,R,S)-AHPC can be conne

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(S,R,S)-AHPC的二维码
  • 库存: 现货
可选规格
  • 包装
    价格
    促销价
    数量
  • 50mg
    ￥2775.00
    2220.00
    - +
  • 100mg
    ￥4312.00
    3450.00
    - +
已选 0 种 0 瓶
金额: ￥0.00
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  • 货号: ajcx33416
  • CAS: 1448297-52-6
  • 别名: VH032-NH2; VHL ligand 1
  • 分子式: C22H30N4O3S
  • 分子量: 430.56
  • 纯度: >98%
  • 溶解度:
  • 储存: Store at -20°C
  • 库存: 现货

Background

(S,R,S)-AHPC (MDK7526, VH032-NH2, VHL ligand 1) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC is potential useful for the targeted degradation of the androgen receptor. (S,R,S)-AHPC can be connected to the ligand for protein such as BCR-ABL1 by a linker to form PROTACs such as GMB-475. GMB-475 induces the degradation of BCR-ABL1 with IC50 of 1.11 μM in Ba/F3 cells.


[1] George M Burslem, et al. Cancer Res. 2019 Sep 15;79(18):4744-4753. [1] Meizhong Jin, et al. WO2016118666A1.

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