Pirtobrutinib

A BTK inhibitor

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库存: 现货

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包装

价格

促销价

数量
5mg

￥762.00

610.00

- +
10mg

￥1350.00

1080.00

- +
25mg

￥3137.00

2510.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajcx33874
CAS: 2101700-15-4
别名: LOXO-305
分子式: C22H21F4N5O3
分子量: 479.43
纯度: >98%
溶解度: DMSO : 50 mg/mL (104.29 mM; Need ultrasonic)
储存: 4°C, stored under nitrogen
库存: 现货

Background

Pirtobrutinib is an inhibitor of Bruton’s tyrosine kinase (BTK).¹ It inhibits wild-type and mutant BTK (IC₅₀s = 10-100 and <10 nM for wild-type BTK and BTK^C481S, respectively). It is selective for BTK over EGFR (IC₅₀ = 1-10 ?M). Pirtobrutinib decreases the number of Ki67-positive cells, a marker of cell proliferation, in MEC-1 chronic lymphocytic leukemia (CLL) mouse xenograft models using MEC-1 cells that express either wild-type BTK or BTK^C481S.²

1.Guisot, N.Compounds useful as kinase inhibitors(2017) 2.Aslan, B., Kismali, G., Iles, L.R., et al.Pirtobrutinib inhibits wild-type and mutant Bruton's tyrosine kinase-mediated signaling in chronic lymphocytic leukemiaBlood Cancer J.12(5)80(2022)