3-Demethylcolchicine

An active metabolite of colchicine

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库存: 现货

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5mg

￥987.00

790.00

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10mg

￥1525.00

1220.00

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25mg

￥3050.00

2440.00

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50mg

￥4750.00

3800.00

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货号: ajcx34426
CAS: 7336-33-6
别名: 3-去甲秋水仙碱
分子式: C21H23NO6
分子量: 385.41
纯度: >98%
溶解度: DMSO : 100 mg/mL (259.46 mM; Need ultrasonic)
储存: 4°C, protect from light
库存: 现货

Background

3-demethyl Colchicine is an active metabolite of colchicine .^1,2 It suppresses antibody production induced by sheep red blood cells in co-culture with isolated mouse spleen cells when used at concentrations ranging from 0.1 to 10 ?g/ml.² 3-demethyl Colchicine (100 ?g/animal) inhibits carrageenan-induced paw edema in rats.³

1.Sch?nharting, M., Mende, G., and Siebert, G.Metabolic transformation of colchicine. II. The metabolism of colchicine by mammalian liver microsomesHoppe Seylers Z. Physiol. Chem.355(11)1391-1399(1974) 2.Sterzl, J., Santav?, F., Sedmera, P., et al.Effect of colchicine derivatives on the antibody response induced in vitroFolia Microbiol. (Praha)27(4)256-266(1982) 3.Sugio, K., Maruyama, M., Tsurufuji, S., et al.Separation of tubulin-binding and anti-inflammatory activity in colchicine analogs and congenersLife Sci.40(1)35-39(1987)