Carubicin hydrochloride

An anthracycline with anticancer activity

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库存: 现货

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数量
5mg

￥4637.00

3710.00

- +
10mg

￥7337.00

5870.00

- +

已选 0 种 0 瓶

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货号: ajcx36984
CAS: 52794-97-5
别名: 盐酸洋红霉素,Carminomycin hydrochloride; Carminomicin I hydrochloride
分子式: C26H28ClNO10
分子量: 549.95
纯度: >98%
溶解度: DMSO : 62.5 mg/mL (113.65 mM; Need ultrasonic)
储存: 4°C, away from moisture
库存: 现货

Background

Carubicin is an anthracycline originally isolated from A. carminata that has anticancer activity.^1,2 It is cytotoxic to MCF-7 and K562 cells (IC₅₀s = 90 and 60 nM, respectively), as well as P-glycoprotein-expressing MCF-7/DOX and K562i/S9 cells (IC₅₀s = 90 and 60 nM, respectively).¹

1.Tevyashova, A.N., Shtil, A.A., Olsufyeva, E.N., et al.Carminomycin, 14-hydroxycarminomycin and its novel carbohydrate derivatives potently kill human tumor cells and their multidrug resistant variantsJ. Antibiot. (Tokyo)57(2)143-150(2004) 2.Gause, G.F., Brazhnikova, M.G., and Shorin, V.A.A new antitumor antibiotic, carminomycin (NSC-180024)Cancer Chemother. Rep.58(2)255-256(1974)