ODN 1826

ODN 1826 为 B 类 CpG ODN (寡脱氧核苷酸)，是一种 TLR9 激动剂。ODN 1826 是一种在小鼠模型中诱导 NO 和 iNOS 产生的极好的免疫刺激剂。 CpG ODN 1826 增强细胞凋亡（ apoptosis）。ODN 1826 序列:5'-tccatgacgttcctgacgtt-3'。

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Background

ODN 1826, a class B CpG ODN (oligodeoxynucleotide), is a TLR9 agonist. CpG ODN 1826 is an excellent immunostimulator that induces NO and iNOS production in the murine model. CpG ODN 1826 enhances cell apoptosis. ODN 1826 sequence: 5'-tccatgacgttcctgacgtt-3'[1][2][3].

[1]. Krogmann AO, et al. Proinflammatory Stimulation of Toll-Like Receptor 9 with High Dose CpG ODN 1826 Impairs Endothelial Regeneration and Promotes Atherosclerosis in Mice. PLoS One. 2016 Jan 11;11(1):e0146326.
[2]. Utaisincharoen P, et al. CpG ODN activates NO and iNOS production in mouse macrophage cell line (RAW 264.7). Clin Exp Immunol. 2002 Jun;128(3):467-73. [3]. Yuan S, et al. CpG oligodeoxynucleotide 1826 enhances the Lewis lung cancer response to radiotherapy in murine tumor. Cancer Biother Radiopharm. 2011 Apr;26(2):203-8.