8-Bromo-cGMP, sodium salt

A cell-permeable cGMP analog

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库存: 现货

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5mg

￥725.00

580.00

- +
10mg

￥1212.00

970.00

- +
25mg

￥2487.00

1990.00

- +
50mg

￥4550.00

3640.00

- +

已选 0 种 0 瓶

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货号: ajci4480
CAS: 51116-01-9
别名: 8-溴代鸟苷-3',5'-环状单磷酸酯钠盐,??8-bromo-cGMP, 8-bromo Guanosine 3’,5’-cyclic monophosphate
分子式: C10H10BrN5NaO7P
分子量: 446.09
纯度: >98%
溶解度: 10mg in PBS(pH7.2)
储存: Desiccate at -20°C
库存: 现货

Background

8-bromo-Cyclic GMP (8-bromo-cGMP) is a cell-permeable analog of cGMP that exhibits greater resistance to hydrolysis by phosphodiesterases than its parent compound. It preferentially activates cGMP-dependent protein kinase.[1] At 1 μM-0.1 mM, 8-bromo-cGMP can inhibit acetylcholine-induced increases in intracellular calcium concentrations.[2]

Reference:
[1]. Rashatwar, S.S., Cornwell, T.L., and Lincoln, T.M. Effects of 8-bromo-cGMP on Ca2+ levels in vascular smooth muscle cells: Possible regulation of Ca2+-ATPase by cGMP-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America 84(16), 5685-5689 (1987).
[2]. Choi, J., and Farley, J.M. Effects of 8-bromo-cyclic GMP on membrane potential of single swine tracheal smooth muscle cells. Journal of Pharmacology and Experimental Therapeutics 285(2), 588-594 (1998).