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PD 118057 是一种 hERG 通道激活剂,不会导致 hERG 阻断。
PD-118057 is a human ether-a-go-go-related gene (hERG) channel activator that does not cause hERG blockade[1].
参考文献:
[1]. Mao H, et al. Pharmacologic Approach to Defective Protein Trafficking in the E637K-hERG Mutant with PD-118057 and Thapsigargin. PLoS One. 2013 Jun 19;8(6):e65481.
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