N-decanoyl-L-Homoserine lactone

A bacterial quorum sensing signal molecule

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货号: ajci4860
CAS: 177315-87-6
别名: 癸酰-高丝氨酸内酯,C10-HSL
分子式: C14H25NO3
分子量: 255.4
纯度: >98%
溶解度: DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml,DMSO: 20 mg/ml,Ethanol: 5 mg/ml
储存: Store at -20°C
库存: 现货

Background

Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. A promising field of study involves controlling bacterial infections by quenching their quorum sensing systems. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by synthesis of diffusible acylhomoserine lactone (AHL) molecules. N-decanoyl-L-Homoserine lactone is a small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism.[1] The applications of this molecule include regulation of virulence and exoproteases.[2]

Reference:

[1]. Barnard, A.M.L., and Salmond, G.P.C. Quorum sensing: The complexities of chemical communication between bacteria Complexus 5(2), 87-101 (2004).
[2]. Williams, P. Quorum sensing, communication and cross-kingdom signalling in the bacterial world Microbiology 153 (Pt 12), 3923-3938 (2007).