Esomeprazole Sodium

An H+/K+-ATPase inhibitor

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库存: 现货

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数量
5mg

￥375.00

300.00

- +
10mg

￥675.00

540.00

- +
25mg

￥1150.00

920.00

- +
50mg

￥1625.00

1300.00

- +

已选 0 种 0 瓶

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货号: ajci5440
CAS: 161796-78-7
别名: 埃索美拉唑钠,(S)-Omeprazole sodium; (-)-Omeprazole sodium
分子式: C17H18N3NaO3S
分子量: 367.4
纯度: >98%
溶解度: ≥ 140.8mg/mL in DMSO
储存: 4°C, sealed storage, away from moisture and light,unstable in solution, ready to use.
库存: 现货

Background

Esomeprazole sodium is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells.IC50 value:Target: proton pumpEsomeprazole sodium (Nexium) is the S-isomer of omeprazole and acts as a proton pump inhibitor and gastric antisecretory agent indicated for the short-term treatment of gastroesophageal reflux disease in patients with a history of erosive esophagitis. Esomeprazole 0.4 and 0.8 mg/mL as the sodium salt in the infusion solutions tested is chemically and physically stable for at least 2 days at room temperature and 5 days under refrigeration.

参考文献:
[1]. Sandstr m M, Davidson G, Tolia V et al. Phase I, multicenter, randomized, open-label study evaluating the pharmacokinetics and safety profile of repeated once-daily doses of intravenous esomeprazole in children 0 to 17 years of age. Clin Ther. 2012 Aug;34(8):1828-38.
[2]. Johnson TJ, Hedge DD. Esomeprazole: a clinical review. Am J Health Syst Pharm. 2002 Jul 15;59(14):1333-9.
[3]. Thomas C Kupiec, Vasileios Aloumanis, Michel Ben, et al. Physical and Chemical Stability of Esomeprazole Sodium Solutions. Ann Pharmacother. September 2008 ,42 ( 9 ):1247-1251.
[4]. Esomeprazole