4β-hydroxy Cholesterol

An oxysterol

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1mg

￥612.00

490.00

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5mg

￥1287.00

1030.00

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10mg

￥2412.00

1930.00

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25mg

￥4775.00

3820.00

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货号: ajci5766
CAS: 17320-10-4
别名: 4Β-羟基胆固醇
分子式: C27H46O2
分子量: 402.7
纯度: >98%
溶解度: ≤20mg/ml in ethanol;0.1mg/ml in DMSO;2mg/ml in dimethyl formamide
储存: Store at -20°C
库存: 现货

Background

4β-hydroxy Cholesterol is an endogenous marker for CYP3A4/5 activity [1].

Cytochome P450 3A4 (CYP3A4) and CYP3A5 are important drug-metabolizing enzymes that oxidize small foreign organic molecules, such as toxins or drugs, and remove them from the body. They exhibit a large variation in hepatic expression and biological activity between different individuals. Patients treated with drugs known to be strong inducers of CYP3A4/5 have highly elevated levels of 4β-hydroxycholesterol in the circulation [1].

4β-hydroxy Cholesterol, an endogenous oxysterol found in human circulation, is formed from cholesterol by cytochrome P450 (CYP) 3A4 and CYP3A5. In 12 different occasions during a 3-month period, The CVs for 4β-hydroxycholesterol ranged from 4.8 to 13.2% with an average CV of 7.1% at an average concentration of 30.8 ng/ml. In 24 volunteers treated with rifampicin, a strong CYP3A4/5 inducer, 4β-hydroxycholesterol increased in a dose-dependent way, while the isomer 4α-hydroycholesterol was not influenced by rifampicin treatment. These results suggested that 4β-hydroxy Cholesterol is an endogenous marker for CYP3A4/5 activity [1].

Reference:
[1].? Diczfalusy U, Kanebratt KP, Bredberg E, et al. 4beta-hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin. Br J Clin Pharmacol. 2009 Jan;67(1):38-43.