Methoxy-X04

Methoxy-X04 是一种荧光染料，可以穿过血脑屏障，选择性地结合在致密中心淀粉样蛋白Aβ斑块中的β-折叠层。Methoxy-X04 保留对淀粉样蛋白 b (Ab) 原纤维的体外结合亲和力 (Ki= 26.8 nM)。Methoxy-X04 具有荧光性，可对阿兹海默症 (AD) 大脑死后切片中的斑块、缠结和脑血管淀粉样蛋白进行染色，具有良好的特异性。

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库存: 现货

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1mg

￥428.00

300.00

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5mg

￥928.00

650.00

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10mg

￥1312.00

1050.00

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25mg

￥2857.00

2000.00

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50mg

￥5429.00

3800.00

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1g

￥9500.00

0.00

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货号: ajci6030
CAS: 863918-78-9
别名:
分子式: C23H20O3
分子量: 344.4
纯度: ＞98%
溶解度: 5 mg/ml in ethanol; 30 mg/ml in DMSO and DMF
储存: Store at -20°C,protect from light
库存: 现货

Background

Methoxy-X04 is a brain-permeable fluorescent probe for amyloid-β (Aβ) to detect and quantify plaques, tangles, and cerebrovascular amyloid.1 It displays high in vitro binding affinity (Ki = 26.8 nM) for fibrillar β-sheet deposits and is used to image Aβ plaques in the brains of living APP/PS1 mice, a transgenic model of familial Alzheimer's disease.[1],[2] For in vivo imaging, APP/PS1 mice were injected with methoxy-X04 at a dose of 10 mg/kg, i.p., 24 hours prior to two-photon imaging.2 Methoxy-X04 displays an excitation peak at 750 nm with emission between 460 and 500 nm.[2]
Methoxy-X04是一种淀粉样蛋白-β（aβ）的脑透性荧光探针，用于检测和量化斑块、缠结和脑血管淀粉样蛋白。1它对原纤维β-片沉积显示出高的体外结合亲和力（Ki=26.8 nM），并用于对家族性阿尔茨海默病的转基因模型APP/PS1活小鼠大脑中的aβ斑块进行成像。[1] ，[2]对于体内成像，在双光子成像前24小时，APP/PS1小鼠以10 mg/kg的剂量腹腔注射甲氧基-X04。2甲氧基-XX4在750 nm处显示出激发峰，发射在460和500 nm之间。[2]
Reference:
[1]. Klunk, W.E., Backsai, B.J., Mathis, C.A., et al. Imaging Aβ plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J. Neuropathol. Exp. Neurol. 61(9), 797-805 (2002).
[2]. Burgold, S., Bittner, T., Dorostkar, M.M., et al. In vivo multiphoton imaging reveals gradual growth of newborn amyloid plaques over weeks. Acta. Neuropathol. 121(3), 327-335 (2011).