Nimorazole

An antimicrobial and radiosensitizer

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1mg

￥1400.00

1120.00

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货号: ajci6468
CAS: 6506-37-2
别名: 尼莫拉唑; K-1900
分子式: C9H14N4O3
分子量: 226.23
纯度: >98%
溶解度: DMF: 10mg/mL,DMF:PBS (pH 7.2) (1:3): 0.25mg/mL,DMSO: 10mg/mL,Ethanol: 2mg/mL
储存: Store at -20°C
库存: 现货

Background

Nimorazole (K-1900) is a nitroimidazole anti-infective.

Nimorazole significantly improves the effect of radiotherapeutic management of supraglottic and pharynx tumors and can be given without major side-effects [1, 2]. Nimorazole is the only such agent to have shown a significant effect in a randomized controlled trial in head and neck cancer [3].

参考文献:
[1]. Overgaard, J., et al., A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85. Radiother Oncol, 1998. 46(2): p. 135-46.
[2]. Roy, R.B., S.M. Laird, and L. Heasman, Treatment of trichomoniasis in the female. A comparison of metronidazole and nimorazole. Br J Vener Dis, 1975. 51(4): p. 281-4.
[3]. Henk, J.M., K. Bishop, and S.F. Shepherd, Treatment of head and neck cancer with CHART and nimorazole: phase II study. Radiother Oncol, 2003. 66(1): p. 65-70.