α-CEHC

A major metabolite of α-tocopherol

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库存: 现货

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1mg

￥312.00

250.00

- +
5mg

￥1437.00

1150.00

- +
10mg

￥2550.00

2040.00

- +
25mg

￥5550.00

4440.00

- +

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货号: ajci6488
CAS: 4072-32-6
别名: γTocopherol Metabolite, GTM, 2,7,8trimethyl2(βCarboxyEthyl)6Hydroxychroman
分子式: C16H22O4
分子量: 278.3
纯度: >98%
溶解度: DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2)(1:1): .25 mg/ml,Ethanol: 10 mg/ml
储存: Store at -20°C
库存: 现货

Background

Molecules having vitamin E antioxidant activity include four tocopherols (α, β, δ, and γ) and four tocotrienols (α, β, δ, and γ). α-Tocopherol is the major lipid soluble antioxidant in vivo and protects against lipid peroxidation. α-CEHC is the major urinary metabolite of α-tocopherol following vitamin E supplementation. The concentration of α-CEHC in human serum is in the range of 5-10 pmol/ml but increases significantly up to 200 pmol/ml upon supplementation with RRR-α-tocopherol. About one-third of the α-CEHC circulating in the blood is present as a glucuronide conjugate. α-CEHC was only excreted when a threshold concentration of 7-9 µmol α-tocopherol/g total lipid in plasma was exceeded. Therefore, excretion of α-CEHC may be considered to be a marker of optimum vitamin E intake.