TCS 5861528

A TRPA1 channel blocker

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库存: 现货

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10mg

￥1325.00

1060.00

- +
50mg

￥5500.00

4400.00

- +
500mg

￥32412.00

25930.00

- +
1g

￥49875.00

39900.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajci6612
CAS: 332117-28-9
别名: TCS 5861528
分子式: C19H23N5O3
分子量: 369.42
纯度: >98%
溶解度: ≥ 76 mg/mL in DMSO with ultrasonic and warming, ≥ 6.17 mg/mL in EtOH with ultrasonic and warming
储存: Store at RT
库存: 现货

Background

Chembridge-5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively).

参考文献:
[1]. Wei H, et al. Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals. Anesthesiology. 2009 Jul;111(1):147-54.
[2]. Wei H, et al. Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat. Neuropharmacology. 2010 Mar;58(3):578-84.
[3]. Wei H, et al. Spinal TRPA1 ion channels contribute to cutaneous neurogenic inflammation in the rat. Neurosci Lett. 2010 Aug 2;479(3):253-6.