SU4312

SU4312 是 (Z)-SU4312 和 (E)-SU4312 的外消旋体。(Z)-SU4312 抑制 PDGFR 和 FLK-1，IC50 分别为 19.4 和 0.8 μM。(E)-SU4312 抑制 PDGFR, FLK-1, EGFR, HER-2, 和 IGF-1R，IC50 分别为 24.2，5.2，18.5，16.9 和 10.0 μM。

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库存: 现货

可选规格

包装

价格

促销价

数量
5mg

￥1100.00

880.00

- +
10mg

￥1850.00

1480.00

- +
50mg

￥5937.00

4750.00

- +
100mg

￥9175.00

7340.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajci7076
CAS: 5812-07-7
别名: NSC 86429
分子式: C17H16N2O
分子量: 264.33
纯度: >98%
溶解度: ≥ 9.45mg/mL in DMSO
储存: Desiccate at -20°C,unstable in solution, ready to use.
库存: 现货

Background

SU4312 is the racemate of (Z)-SU4312 and (E)-SU4312. (Z)-SU4312 inhibits PDGFR and FLK-1 with IC50s of 19.4 and 0.8 μM, respectively. (E)-SU4312 inhibits PDGFR, FLK-1, EGFR, HER-2, and IGF-1R with IC50s of 24.2, 5.2, 18.5, 16.9 and 10.0 μM, respectively[1].

Receptor tyrosine kinases (RTKs) have been shown to be important mediators of cellular signal transduction in cells. Many RTKs have been shown to be oncogene products implicating their role in the transformation process associated with human cancers[1].

[1]. L Sun, et al. Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J Med Chem. 1998 Jul 2;41(14):2588-603.