mGlu2 agonist

mGlu2 激动剂是 2812223 的丙氨酸前药，是一种选择性和有效的正构 mGlu2 受体激动剂。

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库存: 现货

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包装

价格

促销价

数量
5mg

￥2362.00

1890.00

- +
10mg

￥2925.00

2340.00

- +
50mg

￥7437.00

5950.00

- +
200mg

￥17450.00

13960.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajci8150
CAS: 1311385-32-6
别名: (1R,2S,4R,5R,6R)-2-[[(2S)-2-氨基-1-氧代丙基]氨基]-4-(1H-1,2,4-三唑-5-基硫基)-双环[3.1.0]己烷-2,6-二甲酸铵盐水合物
分子式: C13H22N6O6S
分子量: 390.42
纯度: >98%
溶解度: Soluble in DMSO
储存: Store at -20°C
库存: 现货

Background

LY2979165 is a mGlu2 agonist, which is a novel potent agent that is used as anti-depressants.IC50 Value:Target: mGluR

参考文献:
[1]. http://clinicaltrials.gov/ct2/show/NCT01383967
[2]. Hanna L, Ceolin L, Lucas S, Monn J, Johnson B, Collingridge G, Bortolotto Z, Lodge D.Differentiating the roles of mGlu2 and mGlu3 receptors using LY541850, an mGlu2 agonist/mGlu3 antagonist.Neuropharmacology. 2012 Mar 15.
[3]. Ceolin L, Kantamneni S, Barker GR, Hanna L, Murray L, Warburton EC, Robinson ES, Monn JA, Fitzjohn SM, Collingridge GL, Bortolotto ZA, Lodge D.Study of novel selective mGlu2 agonist in the temporo-ammonic input to CA1 neurons reveals reduced mGlu2 recepto
[4]. Liu W, Downing AC, Munsie LM, Chen P, Reed MR, Ruble CL, Landschulz KT, Kinon BJ, Nisenbaum LK.Pharmacogenetic analysis of the mGlu2/3 agonist LY2140023 monohydrate in the treatment of schizophrenia.Pharmacogenomics J. 2012 Jun;12(3):246-54.
[5]. Dominguez C, Prieto L, Valli MJ, Massey SM, Bures M, Wright RA, Johnson BG, Andis SL, Kingston A, Schoepp DD, Monn JA.Methyl substitution of 2-aminobicyclo[3.1.0]hexane 2,6-dicarboxylate (LY354740) determines functional activity at metabotropic glutamate