Antineoplastic agent
货号：ajci9264
CAS：33069-62-4
分子式：C47H51NO14
分子量：853.91
纯度：98%
存储：Store at -20°C
库存：现货
Background:
Paclitaxel, a potent disruptor of microtubules derived from the bark of the Pacific yew tree, is widely used as a chemotherapeutic compound. Tested against a panel of cervical (HeLa), lung (A549), breast (MCF-7), colon (HT-29), ovarian (OVG-1), and pancreatic (PC-Sh) carcinomas, paclitaxel demonstrates IC50 values ranging from 2.5-7.5 nM.1
Paclitaxel disrupts multipolar spindle formation, inducing cell cycle arrest in various human cell cancer lines (IC50s = 6.7-18.5 nM) at both prophase and G1.2
It initiates apoptosis of cancer cells through multiple mechanisms involving p53-dependent and -independent pathways, Bcl-2 family members, cyclin-dependent kinases, and c-Jun N-terminal kinases/stress-activated protein kinases.3
参考文献:
1. Liebmann, J.E., Cook, J.A., Lipschultz, C., et al. Cytotoxic studies of paclitaxel (Taxol) in human tumour cell lines. Br. J. Cancer 68(6), 1104-1109 (1993).
2. Woods, C.M., Zhu, J., McQueney, P.A., et al. Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway. Mol. Med. 1(5), 506-526 (1995).
3. Wang, T.h., Wang, H.S., and Soong, Y.K. Paclitaxel-induced cell death: Where the cell cycle and apoptosis come together. Cancer 88(11), 2619-2628 (2000).
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