Optovin

A photoactivatable TRPA1 ligand

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10mg

￥862.00

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50mg

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货号: ajci9436
CAS: 348575-88-2
别名:
分子式: C15H13N3OS2
分子量: 315.41
纯度: >98%
溶解度: DMF: 25 mg/ml,DMF:PBS(pH 7.2)(1:6): 0.14 mg/ml,DMSO: 20 mg/ml
储存: Store at -20°C
库存: 现货

Background

Optovin is an activator of TRPA1 [1].

Transient receptor potential cation channel, subfamily A, member 1 (TRPA1) is an ion channel that involved in signal transduction and growth control. TRPA1 signaling plays an important role in chronic inflammation and neuropathic pain [1].

Optovin is a photoactivator of TRPA1. In dorsal root ganglia (DRG) sensory neurons isolated from mice, optovin significantly activated 33% (35/105) of DRG neurons, which was not occured in the dark. In HEK293T cells transfected with the human TRPA1, optovin activated cells. Optovin activated TRPA1 channels through a photoactivated intermediate that reacted with redox-sensitive cysteine residues in the channel [1].

In wild-type zebrafish embryos, optovin increased light-dependent motor activity with EC50 value of 2 μM. Optovin induced zebrafish respond to 387-nm light stimuli. Optovin acted on sensory neurons and was not dependent on visual pathways for the increase of light-dependent motor activity. In zebrafish with trpa1b mutant, optovin didn’t have effect, which suggested trpa1b is necessary for optovin activity. In adult mice, optovin induced head-shaking behaviors [1].

Reference:
[1].? Kokel D, Cheung CY, Mills R, et al. Photochemical activation of TRPA1 channels in neurons and animals. Nat Chem Biol, 2013, 9(4): 257-263.