Miglustat

Miglustat (N-Butyldeoxynojirimycin) 是一种具有口服活性的神经酰胺葡糖基转移酶抑制剂。

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库存: 现货

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促销价

数量
5mg

￥1100.00

880.00

- +
10mg

￥1900.00

1520.00

- +
25mg

￥3775.00

3020.00

- +
50mg

￥6475.00

5180.00

- +
100mg

￥11337.00

9070.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajci9504
CAS: 72599-27-0
别名: 美格鲁特; N-Butyldeoxynojirimycin; NB-DNJ; OGT 918
分子式: C10H21NO4
分子量: 219.28
纯度: >98%
溶解度: 44 mg/mL (200.66 mM) in DMSO,22 mg/mL (100.33 mM) in Ethanol, 44 mg/mL (200.66 mM) inWater
储存: Store at -20°C
库存: 现货

Background

Miglustat(OGT918) is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1).Target: OthersMiglustat is an inhibitor of the ceramide-specific glycosyltransferase, which catalyzes the first step of glycosphingolipid biosynthesis and is currently approved for the oral treatment of type 1 GD [1]. Consumption of a standard high-fat breakfast within 30 minutes before administration of miglustat significantly reduced peak exposure but did not significantly affect the extent of systemic exposure to miglustat. The peak plasma concentration (C(max)) decreased by 36% on average following administration with food. Area under the plasma concentration-time curve (AUC(0-infinity)) showed a modest (14%) decrease with food, but the 90% confidence interval was within the acceptance limit of 80% to 125%. The median (min-max) time to C(max) (t(max)) was prolonged from 2.5 (1.0-4.0) hours in the fasted state to 4.5 (1.5-8.0) hours in the fed state, whereas the apparent terminal half-life was approximately 8 hours and not affected by food [2].

参考文献:
[1]. Abian, O., et al., Therapeutic strategies for Gaucher disease: miglustat (NB-DNJ) as a pharmacological chaperone for glucocerebrosidase and the different thermostability of velaglucerase alfa and imiglucerase. Mol Pharm, 2011. 8(6): p. 2390-7.
[2]. van Giersbergen, P.L. and J. Dingemanse, Influence of food intake on the pharmacokinetics of miglustat, an inhibitor of glucosylceramide synthase. J Clin Pharmacol, 2007. 47(10): p. 1277-82.